東吳大學 化學系
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  2. 師資介紹
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  4. 江建緯 副教授

 

江建緯
副教授

 

學經歷

學歷:

  • 2012             國立臺灣師範大學化學系，博士

經歷:

  • 2024/01~迄今  東吳大學化學系  副教授
  • 2021/08~2024/01  東吳大學化學系  助理教授
  • 2016~2020   中國武漢大學學化學院  特聘副研究員
  • 2015~2016  英國劍橋大學化學系  博士後研究員
  • 2013  美國 明尼蘇達大學化學系  訪問學者
  • 2012~2014  國立臺灣師範大學化學系  博士後研究員

聯絡方式
  • 電話(分機) : (02)2881-9471 # 6806
  • E-mail : cwchiang@scu.edu.tw
  • 地址(辦公室) : 台北市士林區11102臨溪路70號超庸館4F-M418室

講授課程
  1. 普通化學(二)
  2. 有機化學
  3. 書報討論

研究方向

實驗室網站：the-chiang-group.com

研究興趣：

  1. 生物共軛化學、生物正交化學及化學生物學
  2. 自由基促進的有機催化合成方法學
  3. 生物無機模擬酶的合成、光譜及反應性

 

研究內容：

生物藥物因其對人體的兼容性高和副作用較小，在近代醫藥領域逐漸發展為新形態的藥物。所以，通過生物共軛和生物正交化學進行多肽和蛋白質的化學標記和藥物修飾合成，也在其中扮演著重要的促進角色。過去，該領域的進展受到穩定的化學修飾方法不足和生物兼容性較差等阻礙，使其發展較為受限。有鑒於此，我們致力於通過各種新形態的自由基促進化學合成方法，如生物無機模擬酶活化、可見光氧化還原催化和電化學合成反應等，來提高生物分子標記的選擇性和生物兼容性。在確保氨基酸標記選擇性的前提下，我們將繼續朝著經由單電子轉移交叉偶合策略的方向努力，針對各種多肽和蛋白質的進行化學修飾和藥物標記，進而實現簡單、高效且溫和的生物修飾反應。

 

 

發表期刊

與專利

  1. 發表期刊論文

    2023

    34. C.-W. Chiang,* K.-W. Jhang, J.-L. Chen, L.-C. Hsu, W.-H. Huang, H.-C. Chen, T.-J. Lin, C.-Y. Sun, and Y.-N. Li, “Promotion of S-nitrosation of cysteine by a {Co(NO)2}10 complex”, Chem. Commun., 2023, D3CC02784H.

    33. C.-W. Chiang,* H.-L. Li, T.-J. Lin, H.-C. Chen, Y.-H. Chou, and C.-J. Chou, “Versatile Synthesis of Symmetric and Unsymmetric Imines via Photoelectrochemical Catalysis: Application to N-Terminal Modification of Phenylalanine”, Chem. Eur. J. 2023, e202301379.

    32. H.-C. Chen, C. Wan, W.-H. Shih, C.-Y. Kao, H. Jiang, Y. Weng,* and C.-W. Chiang,* “Indirect Electrochemical-Induced Trifluoromethylation of Tryptophan Containing Oligopeptides”, Asian J. Org. Chem., 2023, 12, e202200647.

     

    2022

    31. Y. Weng, C.-J. Su, H. Jiang, and C.-W. Chiang,* “Photoredox C-H Functionalization Leads the Site-selective Phenylalanine Bioconjugation“, Scientific Reports, 2022, 12, 18994.

     

    2021

    30. Y. Weng, B. Ding, Y. Liu, C. Song, L.-Y. Chan, and C.-W. Chiang,* “Late-Stage Photoredox C–H Amidation of N-Unprotected Indole Derivatives: Access to N-(Indol-2-yl)amides”, Org. Lett., 2021, 23, 2710-2714.

     

    2020

    29. Y. Weng, C. Song, C.-W. Chiang,* and A. Lei*, “Single electron transfer-based peptide/protein bioconjugations driven by biocompatible energy input”, Commun. Chem., 2020, 3, 171.

    28. C. Song, K. Liu, X. Jiang, X. Dong, Y. Weng,* C.-W. Chiang,* and A. Lei*, “Electrooxidation enables selective dehydrogenative [4+2] annulation between indole derivatives”, Angew. Chem. Int. Ed. 2020, 59, 7193-7197.

    2019

    27. B. Ding, Y. Weng,* Y. Liu, C. Song, L. Yin, J. Yuan, Y. Ren, A. Lei*, and C.-W. Chiang*, “Selective Photoredox Trifluoromethylation of Tryptophancontaining Peptides”, Eur. J. Org. Chem., 2019, 46, 7596-7605.

    26. C. Song, K. Liu, Z. Wang, B. Ding, S. Wang, Y. Weng,* C.-W. Chiang,* and A. Lei,* “Electrochemical Oxidation Induced Selective Tyrosine Bioconjugation for the Modification of Biomolecules”, Chem. Sci., 2019, 10, 7982-7987.

    25. C. Song, X. Dong, Z. Wang, K. Liu, C.-W. Chiang,* and A. Lei*, “Visible-light Induced [4+2] Annulation of Thiophenes and Alkynes to Construct Benzene Rings”, Angw. Chem. Int. Ed. 2019, 58, 12206-12210.

    24．C. Song, K. Liu, C.-W. Chiang,* and A. Lei*, “Recent Advances in the Electrochemical Oxidative Cross-Coupling for the Construction of C–S Bond”, Synlett 2019, 30, 1149–1163.

    23. W. Hao, Y. Sha, Y. Deng, Y. Luo, L. Zeng, S. Tang, Y. Weng, C.-W. Chiang,* and A. Lei* “XANES/EPR Evidence of the Oxidation of Nickel(II) Quinolinylpropioamide and Its Application in Csp3−H Functionalization”, Chem. Eur. J. 2019, 4931-4934.

     

    2018

    22. S. Wang, J. Liu, L. Niu, H. Yi, C.-W. Chiang, A. Lei “Oxidation induced C (sp3)-O cleavage via visible-light photoredox catalysis” J. Photoch. Photobio. A 2018, 355, 120-124.

    21. A. Shao, N. Li, Y. Gao, J. Zhan, C.-W. Chiang*, and A. Lei* “Electrochemical Intramolecular C—H/O—H Cross-Coupling of 2-Arylbenzoic Acids” Chin. J. Chem. 2018, 36, 619–624.

    20. A. Shao, J. Zhan, N. Li, C.-W. Chiang*, and A. Lei* “External Oxidant-Free Dehydrogenative Lactonization of 2-Arylbenzoic Acids via Visible-Light Photocatalysis” J. Org. Chem., 2018, 83, 3582–3589.

    19. C. Song, X. Dong, H. Yi, C.-W. Chiang,* and A. Lei* “DDQ-Catalyzed Direct C(sp3)–H Amination of Alkylheteroarenes: Synthesis of Biheteroarenes under Aerobic and Metal-Free Conditions” ACS Catal., 2018, 8, 2195–2199.

     

    2017

    18. A. Shao, X. Luo, C.-W. Chiang, M. Gao and A. Lei* “Furans Accessed through Visible-Light-Mediated Oxidative [3+2] Cycloaddition of Enols and Alkynes” Chem. Eur. J. 2017, 17874–17878.

    17. J. Wu, Y. Zhou, T. Wu, Y. Zhou, C.-W. Chiang, and A. Lei* “From Ketones, Amines, and Carbon Monoxide to 4-Quinolones: Palladium-Catalyzed Oxidative Carbonylation” Org. Lett., 2017, 6432–6435.

    16. J. Wu, Z. Liao, D. Liu, C.-W. Chiang, Z. Li, Z. Zhou, H. Yi, X. Zhang, Z. Deng*, A. Lei* “From Anilines to Quinolines: Iodide- and Silver-Mediated Aerobic Double C−H Oxidative Annulation–Aromatization” Chem. Eur. J. 2017, 23, 15874–15878.

    15. J. Wu, Y. Zhou, Y. Zhou, C.-W. Chiang, and A. W. Lei* “Electro-oxidative C(sp3)–H Amination of Azoles via Intermolecular Oxidative C(sp3)–H/N–H Cross-Coupling” ACS Catal., 2017, 7, 8320-8323.

    14. L. Lu, D. Cheng, Y. Zhan, R. Shi, C.-W. Chiang, and A. Lei* “Metal-free Radical OxidativeAlkoxycarbonylation and Imidation of Alkanes” Chem. Commun., 2017, 53, 6852 – 6855.

    13. L. Niu, J. Liu, H. Yi, S. Wang, X.-A. Liang, A. K. Singh, C.-W. Chiang, and A. Lei* “Visible-Light-Induced External Oxidant-Free Oxidative Phosphonylation of C(sp2)–H Bonds” ACS Catal., 2017, 7, 7412 – 7416.

    12. H. Niu, L. Lu, R. Shi, C.-W. Chiang,* and A. W. Lei* “Catalyst-free N-methylation of amines using CO2” Chem. Commun., 2017, 53, 1148–1151.

    11. Y. Wu, W. Fu, C.-W. Chiang, P. Choy, F.-Y. Kwong,* and A. Lei* “Palladium-Catalysed Mono-α-Alkenylation of Ketones with Alkenyl Tosylates” Chem. Commun., 2017, 53, 952 – 955

    10. H. M. Wang, Q. Lu, C.-W. Chiang, Y. Luo, J. Zhou, G. Wang, and A. Lei* “Markovnikov-Selective Radical Addition of S-Nucleophiles to Terminal Alkynes via Photoredox Process” Angew. Chem. Int. Ed. 2017, 129, 595 – 599.

     

    2016

    9. H. Wang, G. Wang, Q. Lu. C.-W. Chiang, P. Peng, J. Zhou, and A. Lei* “Catalyst-Free Difunctionalization of Activated Alkenes in Water: Efficient Synthesis of b-Keto Sulfides and Sulfones” Chem. Eur. J. 2016, 22,14489 – 14493.

    8. G. Zhang, X. Hu, C.-W. Chiang, H. Yi, P. Pei, A. K. Singh, and A. Lei* “Anti-Markovnikov Oxidation of β‑Alkyl Styrenes with H2O as the Terminal Oxidant” J. Am. Chem. Soc. 2016, 12037–12040.

    7. H. D. Stout, S, T. Kleespies, C.-W. Chiang, W.-Z. Lee, L. Que, Jr., E. Münck,* and E. L. Bominaar* “Spectroscopic and Theoretical Study of Spin-Dependent Electron Transfer in an Iron(III) Superoxo Complex” Inorg. Chem. 2016, 55, 5215 – 5226.

     

    2014

    6. C.-W. Chiang, S. T. Kleespies, H. D. Stout, E. L. Bominaar,* L. Que, Jr.,* E. Münck,* and W.-Z. Lee* “Characterization of a Paramagnetic Mononuclear Nonheme Iron-Superoxo Complex” J. Am. Chem. Soc. 2014, 136, 10846 −10849.

    5. C.-W. Chiang, Y.-L. Chu, H.-L. Chen, T.-S. Kuo, and W.-Z. Lee* “Synthesis and Characterization of NiIIIN3S2 Complexes as Active Site Models for the Oxidized Form of Nickel Superoxide Dismutase” Chem. Eur. J. 2014, 6283 – 6286

    4. B. Gopula, C.-W. Chiang, W.-Z. Lee, T.-S. Kuo, P.-Y. Wu, J. P. Henschke, and H.-Liang Wu* “Highly Enantioselective Rh-Catalyzed Alkenylation of Imines: Synthesis of Chiral Allylic Amines via Asymmetric Addition of Potassium Alkenyltrifluoroborates to N-Tosyl Imines” Org. Lett. 2014, 16, 632 – 635.

     

    2013

    3. K.-C. Huang, B. Gopula, T.-S. Kuo, C.-W. Chiang, P.-Y. Wu, J. P. Henschke and H.-L. Wu* “Rhodium-Catalyzed Asymmetric Addition of Arylboronic Acids to β-Nitroolefins: Formal Synthesis of (S)-SKF 38393” Org. Lett. 2013, 15, 5730 – 5733.

    2. W.-Z. Lee,* C.-W. Chiang, G. M. Kulkarni, and T.-S. Kuo “Highly Efficient Proline Ester-Based Catalysts for Michael Addition of Thiophenols to α,β-Enones” J. Chin. Chem. Soc. 2013, 60, 245 – 250.

    2012

    1. W.-Z. Lee,* C.-W. Chiang, T.-H. Lin, and T.-S. Kuo “A Discrete Five-Coordinate NiIII Complex Resembling the Active Site of the Oxidized Form of Nickel Superoxide Dismutase” Chem. Eur. J. 2012, 18, 50 – 53.


  2. 專利
    4. 江建緯，劉祐豪”電化學改質生物絲及其製法”中華民國專利第111147470號

    3. Y.-M. Wang, W.-Z. Lee, Y.-J. Chen, S.-C. Wu, C.-W. Chiang, “Use of Ni-SOD mimic compound for manufacture of medicament for cancer treatment” TW 2019/I669120.

    2. W.-Z. Lee，G.-J. LEE，H.-M. Hsieh，C.-W. Chiang，B. Huang，Y.-S. FU，Y.-M. Wang “NiSOD-like compound and its derivatives for suppressing abnormal protein aggregation, recovering cell viability, increasing mature neuron number and neurite outgrowth length and protecting dopaminergic cells by reducing oxidative stress or reactive oxygen species in brain tissues” US 2016/9358239.

    1. W.-Z. Lee, C.-W. Chiang, T.-H. Lin, T.-S. Kuo, “Ni complex and its derivatives, producing method, and the use thereof as an antioxidant”, US 2013/0317224 A1, CA 2788470 A1, CN 103421049A, DE 102012111306A1, TW I449699.

 

 

執行計畫

 

  1. 科技部新進人員研究計畫 (個別型)
    計畫名稱：一氧化氮還原酶活性中心之含鐵或鈷擬態化合物的合成、反應性及應用研究（2021/04/01~2023/07/31）
  2. 科技部新進人員研究計畫 (個別型)
    計畫名稱：一氧化氮還原酶擬態錯合物和光電催化協同策略下的仿生C-H鍵官能化和生物共軛的反應性和機制研究（2023/08/01~2026/07/31）

獎助與榮譽
  1. Postdoctoral Research Abroad Fellowship (MOST), 2014
  2. Certificate of Excellence, Taiwan Scientific Symposium in Oxford, 2015.

 

 

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